Bridge over the Dismal River in the Nebraska Sandhills near Thedford, Nebraska, just south of Valentine.

9 of the Most Scenic Road Trips to Take in Middle America

Middle America is a fond colloquialism that refers to the heart of the United States. The reference implies that these quiet areas are both central geographically, and also refers to the quiet, almost isolated nature of the area. It includes the southernmost midwestern area of the nation, comprising Kansas, Illinois, Indiana, Iowa, Missouri, Ohio, and Nebraska. Its central point is Kansas City, providing easy major-route access throughout the area. Because of the road design, trips in a vehicle often detour into Arkansas, Oklahoma, and even Colorado. This part of the country offers some of the most scenic road trips, perfect for hitting the road with a group of friends, solo trips, or family adventures.

Kansas City, KS to Sioux Falls, SD

Scenic Overlook near Preparation Canyon State Park along the Loess Hills National Scenic Byway, Iowa
Loess Hills National Scenic Byway, Iowa.

Kansas City is the perfect place to start a road trip through Middle America. It has all the useful accommodations to prepare you for the journey ahead. From the city, take the I-29 and head north. Along the side, you can see the Missouri River, the longest in North America. It also provides a view of the Loess Hills, a particular landmark that remains from wind-blown soil. There is a scenic overlook to observe this closer.

From there, maintain a northern route on the I-29, delivering the road tripper straight to Sioux Falls. In this area, there is the official park, but one of its special treasures is the quartzite rocks. These pink wonders glimmer underneath the Sioux River and bring wonder to Middle America, making it an ideal beginning or end of a trek. The trip takes around five hours and is worth every moment of the drive.

Topeka, KS to Rapid City, SD

Road through the green pasture land in the Flint Hills of Kansas
Green pasture land in the Flint Hills of Kansas.

Topeka is quieter than many other large locations on the map, but it provides quick roadside access to amenities and allows the driver to continue the journey. Taking a northern route along the I-29, after leaving Topeka, follow this path until the western turnoff to the I-90. Best in the daytime, this area is an open wonder of grasslands, exemplifying the peace of the prairies. Known as the Flint Hills, this area is a unique biome.

After traveling north to Rapid City, there are views of Mount Rushmore, showing both a historical landmark and the wonders of the granite hill-scape. A lengthy trek, the route takes just over 10 hours, covering an impressive 687 miles. For comfortable stopovers, Sioux City makes a fine selection.

Valentine, NE to Oklahoma City, OK

Aerial view of sandy road in Nebraska Sandhills near Seneca, spring scenery with morning light
 Nebraska Sandhills near Seneca, at the border before you cross into Oklahoma.

Valentine is a cozy area, where nature overcomes the quick pace of city life. Ideal for a midpoint in a road trip, the driver heads south on I-83, and eastward through the countryside to meet up with the I-35 south to Oklahoma City. The Nebraskan sandhills feature prominently in the background during this 10-hour trek, and as the sun sets, it provides a magical imprint of the open space. After arriving in Oklahoma City, there are plentiful amenities of a major hub, along with a memorial from a 1995 bombing. It is a good resting space, with ample chances to explore nature and the city alike.

Tulsa, OK to Ohio City, OH

Road and sign on the Historic Route 66 in Tulsa Oklahoma
Historic Route 66 in Tulsa, Oklahoma. Image credit 4kclips via Shutterstock

Tulsa is a well-known area that provides access to the I-44, taking the trip northeastward, across Cherokee Nation, through Springfield, and past St. Louis. Taking a total of 14 hours to travel, this 950-mile journey has many enjoyable stops along the way. Springfield, Missouri, is an ideal place to rest, eat, and appreciate the essence of middle America. Upon arriving in Ohio City, road-trip enthusiasts can see the Rock & Roll Hall of Fame, Edgewater Park, and the classic West Side Market.

Poplar Bluff, MO to St. Louis, MO

Highway over the water and the St Louis Missouri Skyline
The highway into St Louis, Missouri.

Aptly named, Poplar Bluff is home to a plethora of woodlands, providing insight into the diversity of the area. Heading north via the US-67, the trek runs through the Ozark region's riverways, an official national park that shows clear waters and beautiful wildlife. The park itself highlights the Jacks Fork River and Current River against a backdrop of bluffs.

Following the same northern route, the arrival point is St. Louis. In this proud city, there is the Gateway Arch and chances to see the Mississippi River from a gondola. A mere two-and-a-half-hour trip, it is an easy day trip for middle America enthusiasts.

Cincinnati, OH to Cedar Rapids, IA

Red farm in historic Amana colonies in in east-central Iowa state
Red farm in historic Amana colonies.

The route from Cincinnati to Cedar Rapids follows a diagonal trajectory. Taking the I-74, the 501-mile journey takes around seven hours to complete.  Along the way, you can take in the sights of the Amana Colonies. This unique set of seven villages remains from German immigrants during the 19th century. Once in Cedar Rapids, there is a chance to view both natural and artistic wonders. It hosts the Cedar Rapids Art Museum, featuring the works of many famed artists. 

Davenport, IA to Omaha, NE

Des Moines is the Urban Capitol of the the Rural State of Iowa
Driving through Des Moines, Iowa.

Just a quick jaunt over from Cedar Rapids, Davenport takes the road trip further west along the I-80. Taking approximately five and a half hours, the drive runs right through Des Moines, making for an ideal stop halfway through the trek. Once in Omaha, there are several indoor and outdoor adventures for a road trip.

The Henry Doorly Zoo features animals from a global population and features the largest known indoor desert. The comparison of the indoor features and the outside landscape makes both even more wondrous. With so much to do, it makes sense to rest up in Omaha before circling back the 300-mile journey.

Joplin, MO to Little Rock, AR

Its a beautiful day on the riverfront in the State Capitol city of Little Rock Arkansas
Bridges leading into Little Rock, Arkansas.

Joplin is a good starting point, with Grand Falls being a key tourist attraction. To get to Little Rock, follow I-49, then go east on I-40. The trip takes around four hours, moving in a southeastern direction. This provides a different vantage point for the Ozarks and offers access to the Buffalo National River.

This area is legally a scenic route for its ecological protection. It covers immense bluffs and rough terrain, only for the water to emerge clear and beautiful. Once the road trip gets to Little Rock, there are opportunities for walks in the unique area. It also features the Clinton Presidential Center Park, a historical landmark for the area.

Des Moines, IO to Bloomington, IN

Bloomington, Indiana, the business district on Kirkwood Avenue
Take a rest in Bloomington, Indiana. Image credit Roberto Galan via Shutterstock

Des Moines is a major hub, making it an ideal starting point or conclusion for a road trip. Heading eastward along the I-80, the trip brings you across the open plains. Eventually, the I-74, Iowa's division between Davenport and Bettendorf, provides access to Bloomington. Taking approximately eight hours of travel, the city provides ample entertainment through its art and science museums. Replete with accommodations, it is easy to recharge in Bloomington, then move through Indianapolis to continue the road trip. 

These road trips present some of the most hidden gems in the United States. Out of the way, without being inaccessible, you can also follow each route sequentially. This provides a comprehensive view of Middle America and allows for travel via back roads and the interstate. Throughout the journey, there are ample accommodations, including hotels, motels, restaurants, and other local attractions of each major hub.

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