The bird's eye view of Dearborn Circuit Court Clerk Lawrenceburg, Indiana, United States

This Indiana Scenic Byway Is The Road Trip Of A Lifetime

Running along the northern bank of the Ohio River, the Indiana section of the Ohio River Scenic Byway offers travelers an unforgettable road trip through time, terrain, and texture. Spanning roughly 300 miles across southern Indiana, this route weaves together historic river towns, lush forested hills, sweeping river bluffs, and quirky local highlights. On one hand, it tells the story of Native American civilizations, steamboat commerce, and frontier life; on the other, it invites you to slow down, peek into antique shops, stroll charming Main Streets, pause by the water’s edge, and simply breathe. Whether you are drawn by outdoor adventure, heritage architecture, or the gentle rhythm of small-town river life, this byway truly feels like the road trip of a lifetime.

Route Overview

downtown new Albany Indiana river view.
Downtown, New Albany, Indiana, river view.

The journey begins near the Indiana-Ohio border and continues westward to the border with Illinois, clinging to the river’s edge while rolling through hills, valleys, forests, and farmland. The Indiana portion of the byway covers about 302 miles, and the entire 943-mile route (including the Ohio and Illinois sections) was designated a National Scenic Byway in 1996. Along the way, drivers follow a combination of State Routes 50, 56, 62, and 66 and local roads, meandering through towns like Madison, Corydon, and New Albany, and the city of Evansville. The terrain changes from orchard-dotted farmland to steep forested bluffs overlooking the river, and features key side trips such as caves, fossil beds, and national memorials. This route is not about high speed but low stress, with winding curves, scenic pull-offs, historic districts, and scenic overlooks that invite unscheduled breaks. Its charm lies in how the past and present meet—industrial relics, steamboat heritage, Native archaeology, and contemporary artisan communities all sit side by side. For those who drive with time to wander, the Indiana segment of the Ohio River Scenic Byway presents an immersive cross-section of Hoosier culture, geology, and riverside serenity.

Eastern Section

A view from Madison, Indiana, bank of the Ohio river.
A view from Madison, Indiana, bank of the Ohio River.

Beginning at the Ohio border, the first must-visit town along the route is the vibrant riverfront community of Madison. Start by soaking in the river views along the beautifully landscaped Madison Riverfront Park, with gazebos and brick walkways hugging the banks of the Ohio. Then explore the rich historic core of the town in the Madison Historic Business District, which spans 133 blocks and boasts hundreds of 19th-century structures.

Lanier Mansion north elevation.
Lanier Mansion north elevation. By Landry76 - Own work, CC BY-SA 4.0, Wikipedia.

History comes to life at the Lanier Mansion State Historic Site, a spectacular Greek-Revival home where you can learn about a prominent figure tied to Indiana’s Civil War efforts. From there, step into nature at Clifty Falls State Park, with its dramatic hiking trails, plunging waterfalls, and scenic overlooks just minutes from town. Beyond these, consider detours to Hanover College, perched on a bluff, or Hanover’s historic Main Street. This byway segment delivers riverfront calm, historic architecture, and wild outdoor scenery, setting the tone for the rest of the journey.

East Central Section

O'Bannon Woods State Park Nature Center.
O'Bannon Woods State Park Nature Center. By Bedford at English Wikipedia - Own work, Public Domain, Wikipedia.

As you press westward on the byway, the landscape becomes more heavily forested. The next key stop is the town of Corydon, home to the Corydon Capitol State Historic Site, where Indiana’s first state constitution was drafted, and early government buildings still stand. Just west of Corydon lies the fascinating Wyandotte Caves, featuring guided tours through limestone chambers draped in flowstone and hosting several bat species. If a break in the forested hills is welcome, head to O’Bannon Woods State Park, which offers hiking, canoeing, and trails with sweeping views over the river valley. This whole middle section of the route rewards those who slow down with scenic overlooks, curving roads that cling to bluffs, and woodland patches that hint at something wild just off the highway.

West Central Section

The National Park Service Site of Lincoln's Boyhood home.
The National Park Service Site of Lincoln's Boyhood Home.

Continuing further west takes you into a more rugged and remote stretch of southern Indiana, where the byway hugs the river and dips into forest and farmland. In the town of Tell City, stop at the Statue of William Tell, celebrating the Swiss heritage of the town, and enjoy the pretzel-making tradition at the Tell City Pretzel Company. A short drive brings you to the Lincoln Boyhood National Memorial in Lincoln City, where a cabin site, living historical farm, and walking trail commemorate the youth of Abraham Lincoln.

Evansville, Indiana, USA.
Evansville, Indiana, USA. Editorial credit: Roberto Galan / Shutterstock.com

Next, ride into the historic riverside town of Newburgh. Here, the Newburgh Locks and Dam observation area offers excellent river-traffic views, and the downtown district is perfect for browsing antiques and cafes. Finish this leg by arriving in Evansville, the region’s urban center. Take time to visit the Angel Mounds State Historic Site, a superbly preserved Mississippian culture town on the riverbank, and wander in the Riverside Historic District. This segment brims with variety: small-town charms, national heritage sites, forested hills, and river vistas all in a single stretch.

Western Section

Mount Vernon, Indiana, USA.
Mount Vernon, Indiana, USA. Editorial credit: Roberto Galan / Shutterstock.com

From Evansville to Mount Vernon, the last stretch of Indiana’s leg of the Ohio River Scenic Byway offers a tranquil finale of rolling farmland, hardwood forest, and sweeping river views. The road leads into Mount Vernon, where travelers can relax along the Ohio River at Riverbend Park, a scenic green space with walking trails and gazebos overlooking the water. In downtown Mount Vernon, historic architecture frames inviting shops and eateries such as Hawg N Sauce Barbecue, perfect for a hearty local meal. Nearby, Hovey Lake Fish and Wildlife Area provides peaceful wetlands for bird-watching and kayaking, while a return to Riverbend Park offers an ideal spot to watch the sunset paint the river in gold—an unforgettable conclusion to the Indiana section of the byway.

Hoosier History and Hospitality

The Indiana portion of the Ohio River Scenic Byway is a multi-layered experience that brings together geology, human history, and natural scenery like few routes can. From the cobblestone riverfront walkways of Madison to the underground chambers of Wyandotte Caves, from Lincoln’s boyhood memories to the ancient mounds of the Angel culture, each mile reveals a new facet of the region. It's quiet towns, winding roads, and hidden overlooks encourage you to pull off the map, linger a little, and let the river soundtrack your journey. In an era of high speeds and automated itineraries, this byway rewards presence, curiosity, and time. Whether you complete the full 302 miles or focus on a single section, this route will stay with you long after you finish the drive.

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