12 Ideal South Carolina Destinations for a 3-Day Weekend in 2025

Genuine Southern hospitality, pristine natural beauty, and unique cultural elements lure travelers to the Palmetto State. But there is more to experience in this East Coast gem, especially when you choose to explore beyond its bustling cities. A detour to the countryside reveals charming small towns with rich history, bursting with character. From the moss-draped oaks of Beaufort to the Revolutionary War sites in Camden, South Carolina, offers the perfect blend of relaxation and discovery.

Whether chasing outdoor adventures, savoring Lowcountry cuisine, or strolling through cobblestone streets steeped in history, the state’s hidden gems shine brightest during a short-lived escape. Here are some of the best South Carolina destinations for a 3-day weekend in 2025.

Newberry

On paper, Newberry looks like your typical small town, but you have to visit to discover its beautiful backstory and experience its vibrant arts and theater scene, a mere 45 minutes from Columbia. The Newberry Museum documents the community's heritage in a diverse library of history, art, and military artifacts. Being a college town, the city center is always buzzing with activity, and at the heart of it all is the Newberry Opera House. This landmark venue entertains the community with lively concerts, operas, dramas, and other productions by professional artists.

Meanwhile, Wells Japanese Garden rewards tourists who opt to skip the downtown noise and revel in the quiet of a green oasis with manicured gardens, pristine ponds, and gentle trails designed for relaxation. For your lodging, the restored Newberry Manor blends rustic appeal and modern elegance in a 1900s inn to deliver a comfortable night's sleep.

Clover

It's easy to fall in love with this tiny village of York County. Clover's Open Air Flea Market is an excellent place to hunt for treasure with an eclectic mix of vintage items and unique finds. Meanwhile, Clover Community Park has a wide range of amenities for recreation and leisure, including picnic areas, sports fields, an amphitheater, a disc golf course, horseshoe pits, and a walking trail.

The busy Main Street offers delightful opportunities for art enthusiasts, with a chance to browse intimate creations by emerging and established artists at Gallery 120. Along the same street, you can find a warm and inviting spot to lay your head for the night at Magnolia House and Gardens B&B.

Georgetown

Just 60 miles from Charleston, Georgetown was founded in 1729 and preserves its heritage at numerous landmarks throughout the town, including the Kaminski House Museum. You can take a guided tour of the 18th-century home and see period memorabilia and antiques that offer a glimpse of life during the period. Meanwhile, Georgetown's nautical legacy is on display at the South Carolina Maritime Museum, featuring a vast collection of photos, documents, and artifacts.

For a bit of outdoor recreation, head to the Harborwalk, a beautiful promenade overlooking the Georgetown Harbor. A string of restaurants, shops, and pubs along the corridor culminates in a busy social hub. When it's time to call it a night, the stunning new George Hotel is conveniently located in the historic district along the waterfront.

Camden

Three days may not be enough to explore all of Camden's unique attractions, but you can expect to be widely impressed by its historic significance. The community was founded in 1733 and was the site of the worst Patriot defeat of the Revolutionary War at the Battle of Camden. Today, you can visit the Historic Camden Revolutionary War Site. This 100-acre living history complex features Kershaw House, circa 1778, a blacksmith forge, and several other buildings and artifacts from the war. Meanwhile, guests can take a deeper dive to discover the genesis and evolution of the conflict at the Revolutionary War Visitor Center, which highlights Camden's pivotal role in the Southern campaign.

But there is more to experience in Camden beyond war history. For outdoor lovers, Goodale State Park presents a serene lakeside sanctuary with walking trails, picnic spaces, fishing spots, and boat ramps for those who wish to access Pine Tree Creek. Lastly, Hampton Inn Camden welcomes guests to spend the night at a convenient location near the Revolutionary War site.

Beaufort

This hidden getaway on Port Royal Island is one of the most sought-after South Carolina destinations for a 3-day weekend in 2025, thanks to a pleasant mix of rich history and appealing natural scenery. Beaufort hosts a historic district with elaborate antebellum mansions, such as the John Mark Verdier House. Built in 1804, this Federal-style dwelling is a vivid window into the life of an upper-class citizen in Beaufort during the period. However, the Beaufort History Museum digs deeper into the town's rich past, with memorabilia and exhibits on display inside an 18th-century armory.

Beaufort's natural setting is best experienced during leisurely strolls at Henry C. Chambers Waterfront Park. This serene space boasts a peaceful promenade overlooking the Beaufort River, with picnic areas for those who want to simply relax and watch the boats go by. One of the best lodging options in the area is the Hilton Garden Inn Beaufort, situated within walking distance of the historic district.

York

From its historic district to its shopping centers and natural areas, York promises vacationers a well-rounded experience. Downtown is a social and cultural hub, anchored by the McCelvey Center. The historic venue was built in 1852 and was the original site of the Yorkville Female College. Now, it is an event space and hosts an annual live performance series in the 500-seat Lowry Family Theater. Casual shoppers will enjoy Yorkville Marketplace, where local vendors sell everything from food and clothes to antiques in a lively setting.

Meanwhile, those craving time spent outdoors can head to Spring Lake Country Club for a friendly game of golf on manicured greens surrounded by lush trees and a reservoir. When you need a rest, Deluxe Inn is a worthy choice conveniently located near the golf course and the McCelvey Center.

Bluffton

Bluffton is a fast-growing municipality in Beaufort County with an eclectic mix of art galleries, performance art venues, and a walk-friendly historic district. The town is home to a vibrant community of artists and the May River Theatre, which hosts a range of plays and musicals throughout the year. The Farmers Market attracts dozens of local vendors with their assorted wares, welcoming tourists for a unique shopping experience that includes baked goods, homegrown produce, fresh flowers, and other local specialties.

You can also enjoy a trip down memory lane while strolling around the historic district, home to Heyward House Museum, which offers a peek into 19th-century life in South Carolina. When you need to rest for the night, Holiday Inn Express & Suites Bluffton is an excellent choice.

Florence

Florence is a quintessential Southern community with an attractive blend of live entertainment venues, restaurants, boutiques, and outdoor recreation opportunities. Those in need of a little retail therapy will enjoy Magnolia Mall, and souvenir hunters can find all sorts of treasures at Palmetto Peddlers Antique Mall. Meanwhile, the Francis Marion University Performing Arts Center hosts a wide variety of concerts, plays, and other community events in a beautiful complex that includes two theaters and an amphitheater.

Florence allows you to escape the crowds and breathe in some fresh air at Timrod Park. This tranquil refuge sits on 18 acres and provides picnic areas, a gazebo, pickleball and tennis courts, and a gazebo. In terms of accommodations, Hotel Florence is a beautiful option. Set in a restored heritage building in the heart of the historic district, the hotel includes a full-service spa and restaurant on site.

Travelers Rest

As suggested by its name, Travelers Rest allows tourists to relax and rejuvenate during a low-key vacation, promising remarkable culinary experiences and escapes into nature. This charming village in Greenville County is dotted with dining and drinking establishments, like Farmhouse Tacos, a popular spot for Tex-Mex in a casual, vibrant setting. Wellborn Winery is also a great spot to whet your whistle. They have a tasting area and invite visitors to tour the sprawling vineyard.

Furthermore, there are numerous opportunities for the outdoor enthusiast in Travelers Rest. Bunched Arrowhead Heritage Preserve offers gentle walkways through a rich ecosystem of native flora and fauna worth exploring. For an unforgettable experience, book your stay at European-inspired Hotel Domestique. The rooms and luxury suites are impeccable, and the ammenities are unmatched.

Anderson

Anderson boasts spectacular vistas of Lake Harwell, which also fuels an array of aquatic-based adventures. The reservoir is a hub for boaters, fishermen, and paddlers, particularly at Sadlers Creek State Park. On the other hand, tourists who prefer indoor activities can check out sophisticated art exhibitions or attend an informative workshop at the Anderson Arts Center.

Alternatively, you can explore the community's heritage at the Anderson County Museum. This resourceful center showcases important archives and documents chronicling Anderson's past. For accommodations that match comfort with convenience, Hilton Garden Inn Anderson is one of the many lodging options available to guests, situated near the shores of Lake Harwell.

Myrtle Beach

Nothing relaxes the mind, body, and soul better than a short sojourn along South Carolina's sandy coast, and this is exactly what to look forward to in Myrtle Beach. A 60-mile shoreline spoils tourists with prime beachside real estate, ideal for lounging, picnicking, beachcombing, and sightseeing. For a bit of fun in the sun, head to Myrtle Beach State Park, the first state park in South Carolina, where you will find a pristine beach, miles of hiking trails, picnic facilities, and a fishing pier. The Ripley's Aquarium of Myrtle Beach also impresses with its delightful display of aquatic wildlife, including stingrays, jellyfish, and horseshoe crabs.

Myrtle Beach is home to a string of amusement parks, and those craving a thrilling experience and a bird's-eye view should check out SkyWheel Myrtle Beach for an unforgettable ride. There is certainly no shortage of accommodations in town, with choices range from large resorts to cozy condos. North Beach Resort and Villas offers a nice mix of options with something for most budgets.

Orangeburg

Orangeburg blends historical lore, cultural heritage, and outdoor adventure to guarantee travelers a jam-packed long weekend. The town boasts a rich backstory dating back to the early 18th century, which you can explore at the Orangeburg County Historical Society. It is also home to an active community of artisans and creatives, whose main gathering hub is the Orangeburg Fine Arts Center. Here, visitors can peruse a collection of works by homegrown talent or attend a lesson to indulge their artistic side.

Meanwhile, Edisto Memorial Gardens is a picturesque oasis along the Edisto River. Wander among award-winning roses, native plants, and cypress trees in a space named in honor of those who gave their lives in combat. For a comfortable stay, Tru by Hilton is a popular spot with a gym and complimentary breakfast.

Final Thought

Whether you need a break from the chaotic urban scene or just a change of scenery, these South Carolina destinations for a 3-day weekend in 2025 offer the perfect escape. From historic towns rich with Southern charm like Bluffton to coastal resorts like Myrtle Beach, the Palmetto State delivers variety, beauty, and relaxation in equal measure in the United States. In just a few days, you can recharge, explore, and reconnect with nature, culture, and yourself, turning each weekend into a vacation to remember.